The centromere and its epigenetic nature

by Jahnvi Sharma



Centromeres are essential for the separation of chromosomes throughout the cellular division. They are enigmatic structures since, contrary to different genetic loci, the operation of centromeres isn't determined by the underlying deoxyribonucleic acid sequence, however it depends on epigenetic factors. especially, complex body part body substance is peculiar for the presence of a changed H3 simple protein, CENP-A, and a variety of proteins forming a fancy named CCAN (Constitutive kinetochore Associated Network). Moreover, centro chromatin is defined by simple protein modifications whose role in kinetochore operation remains debated. Mammalian centromeres are a unit generally associated with extremely repetitive deoxyribonucleic acid (satellite DNA); this pattern of organisation hampered an in-depth molecular analysis of complex body part body substance.



The perissodactyl mammal model system- Our analysis cluster is incontestable, for the primary time, the existence in nature of satellite-free centromeres that are unit stable and useful. These centromeres area unit gift during a variety of chromosomes within the genus Equus (horses, donkeys, zebras), they represent a novel model system for the study of the epigenetic management of kinetochore operate and of its role in makeup evolution It is accepted that alterations in the body segregation area unit are liable for the incidence of numerical body abnormalities discovered within the massive majority of tumours. The perissodactyl mammal model system offers the chance to research the mechanisms concerned with the numerical body instability associated with the event and progression of the many different types of cancer.

The absence of repetitive deoxyribonucleic acid at the kinetochore of a variety of perissodactyl mammal centromeres makes it potential to review the bailiwick organisation of centrochromatin and, especially, the role of deoxyribonucleic acid methylation, transcription and simple protein modifications.

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