Glucomimetics

By Jahnvi Sharma


Glucomimetics is the term used to refer to molecules that are structurally similar to carbohydrates, but with changes that often lead to changes in biological properties. Structural changes often occur around the glycosidic link. Replacement of one or more glycosidic oxygen atoms with carbon, sulfur, nitrogen, etc. modifies the properties of the glycosidic bond. The molecules produced are called carbosugars or C-glucosides, thiosugars or thioglucosides, or imino sugars or glycosylamines. When nitrogen is injected, the glucomimetic can become positively charged at physiological pH, which means it can act as an enzyme inhibitor by Coulomb interaction with the side chains of amino carboxylate acids at the site of enzyme activity, or by mimicking the accumulation of a positive charge upon conversion. response state, or both. Aminosugars (sometimes mistakenly called azaleas) are classic examples of molecules with this behaviour. The substitution of CF2 for methylene was investigated in an attempt to solve this problem and obtain a better mixture while maintaining the hydrolytic stability achieved by modification. Examples of Commercially Related Glucomimetic Molecules: Tamiflu Tamiflu is a carbocyclic mimic of the sialic acid carbohydrate on the cell surface. Tamiflu is an enzyme inhibitor that blocks the action of the neuraminidase (sialidase) of the influenza virus. Acarbose Acarbose is a pseudotetrasaccharide that mimics maltotetraose (starch substructure). One of the glucose units has been replaced by valienamine, a carbohydrate sugar that is linked to the next carbohydrate by an amine bridge. Another unit of glucose is represented as the 6-deoxy variant. Acarbose is an enzyme inhibitor used as a drug against type 2 diabetes. Miglustat Miglustat is an iminosugar in which the oxygen in the ring is replaced by nitrogen. Miglustat is a medicine used to treat certain rare diseases of lysosomal storage disorders.

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